Alprenolol hydrochloride

Research use only, not for human use.

Alprenolol hydrochloride is a non-selective blocker of beta, and also is a antagonist of5-HT1A receptor.

Alprenolol hydrochloride is a non-selective blocker of beta, and also is a antagonist of5-HT1A receptor.

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Alprenolol (p.o., 50 mg/kg) hydrochloride causes a significant drop in blood pressure which averages 20 mm Hg (at 3-hr) and an increase in heart rate by 39 beats/min (at 3-hr) in conscious renal hypertensive dogs.Alprenolol (i.p., 5 mg/kg) hydrochloride effectively blockes the anxiolytic effects of indorenate and ipsapirone but do not reduce the motor activity in adult male Swiss Webster mice.Alprenolol (intravenous injection, 0.5 or 1.0 mg/kg) can decrease systolic pressure by a mean of 10 mm Hg, diastolic pressure by a mean of 10 mm Hg) hydrochloride and heart rate by 23 beats/min, as well as slightly reduce both myocardial and liver blood flows by mean of 17% and 15% respectively at a dose of 1.0 mg/kg in cats.

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Endocrinology/Hormones

5-HT Receptor

5-HT1A

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13707-88-5

285.81

C15H24ClNO2

>98% (HPLC)

DMSO:95 mg/mL (332.39 mM; Need ultrasonic); H2O:50 mg/mL (174.94 mM; Need ultrasonic)

Cl.CC(C)NCC(O)COc1ccccc1CC=C

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(-20℃)

With Ice Pack

≥ 2 years